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연구분야 (Research Field)
I. Cancer cell invasion and migration
Cancer invasion is an important initial event in the multistep process of metastasis




Cells migrate either individually (A) of collectively (B) with plasticity of invasion modes (C,D).
Lodish et al., Molecular Cell Biology, 9e, Ch.25

Cancer cell invasion involves alterations in cell-cell interaction and cell-matrix interaction, leading to extracellular matrix remodeling (A) and epithelial-mesenchymal transition (EMT) (B).
DOI: 10.1016/j.cell.2011.11.016
DOI: 10.1016/j.cell.2011.11.016
II. 3D in vitro tumor model



III. Significant role of 3D tumor models in developing new cancer treatment

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