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​연구분야 (Research Field)

I. Cancer cell invasion and migration

Cancer invasion is an important initial event in the multistep process of metastasis

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Cells migrate either individually (A) of collectively (B) with plasticity of invasion modes (C,D).

Lodish et al., Molecular Cell Biology, 9e, Ch.25

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Cancer cell invasion involves alterations in cell-cell interaction and cell-matrix interaction, leading to extracellular matrix remodeling (A) and epithelial-mesenchymal transition (EMT) (B).

DOI: 10.1016/j.cell.2011.11.016

DOI: 10.1016/j.cell.2011.11.016

II. 3D in vitro tumor model

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III. Significant role of 3D tumor models in developing new cancer treatment

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