국내외전문학술지 (Publications)
2023
Hyun-Ah Kim, Jong-Kook Park, Moo-Yeal Lee, Hyun-Soo KIM , Seok Chung, Kyung-Mi Lee, Hyo-Jeong Kuh. Suppression of the antitumoral activity of natural killer cells under indirect coculture with cancer-associated fibroblasts in a pancreatic TIME-on-Chip model. Cancer Cell Int. 2023 Sep 27;23(1):219. doi: 10.1186/s12935-023-03064-9. (https://pubmed.ncbi.nlm.nih.gov/37759302/) [Citation Counts 3 as of May 2024]
Kwang-Seock Kim; Si-Hyoung Kim; Chang-Nim Im; Kun Na; Moo-Yeal Lee; Jong-Kook Park; Hyo-Jeong Kuh. Effect of paclitaxel priming on doxorubicin penetration in a multicellular layer model of human colorectal cancer cells. Biochem Biophys Res Commun. 2023 Mar 5;647:30-36. doi: 10.1016/j.bbrc.2023.01.063. (https://pubmed.ncbi.nlm.nih.gov/36709670/) [Citation Counts 1 as of May 2024]
2022
Hyun-Ah Kim, Si-Hyoung Kim, Hyo-Jeong Kuh. Effect of cancer-associated fibroblasts on natural killer cells-mediated tumor cell kill: A study using a microfluidic 3D in vitro tumor model of pancreatic tumor. [Poster, 2022 한국응용약물학회 추계 학술대회, 2022 Oct]
Sook-Jin Oh, Hyo-Jeong Kuh. Analysis of antitumor activity of stromal targeting agents in 3D tumor spheroid-CAF co-culture model [Poster, 2022 Annual Meeting and International Conference of the KSPST, 2022 Dec]
Hyun-Ju Hwang, Hyo-Jeong Kuh. Heterotypic CAF-tumor spheroids for cancer cell invasion in human gastric cancers [Poster, 2022 Annual Meeting and International Conference of the KSPST, 2022 Dec]
2021
Jang SD , Song JY , Kim HA, CN , Iftikhar Ali Khawar , Park JK and Kuh HJ. Anti-Cancer Activity Profiling of Chemotherapeutic Agents in 3D Co-Cultures of Pancreatic Tumor Spheroids with Cancer-Associated Fibroblasts and Macrophages. Cancers
(2021. 13(23):5955 (https://azar-innovations.com/3d-pancreatic-tumor-spheroids-co-cultured-with-stromal-cells-in-an-organ-on-a-chip-to-study-drug-resistance-and-cell-cell-interaction/) [Citation Counts 13 as of May 2024]
Khawar, I.A., Ghosh, T., Park, J.K., Kuh, H.-J. Tumor spheroid-based microtumor models for preclinical evaluation of anticancer nanomedicines. J. Pharm. Investig. 51, 541–553 (2021). [Citation Counts 13 as of May 2024]
Yun BD, Son SW, Choi SY, Kuh HJ, Oh T-J, Park JK. Anti-Cancer Activity of Phytochemicals Targeting Hypoxia-Inducible Factor-1 Alpha. International Journal of Molecular Sciences. 2021; 22(18):9819. [Citation Counts 18 as of May 2024]
Son SW, Yun BD, Song MG, Lee JK, Choi SY, Kuh HJ, Park JK. The Hypoxia–Long Noncoding RNA Interaction in Solid Cancers. International Journal of Molecular Sciences. 2021; 22(14):7261. [Citation Counts 10 as of May 2024]
Jung, S. Y., Lee, H. K., Kim, H., Kim, S., Kim, J. S., Kang, J. G., Kuh, H. J., Yoo, J. S., Ko, J. H., & Lee, J. H. Depletion of ST6GALNACIII retards A549 non-small cell lung cancer cell proliferation by downregulating transferrin receptor protein 1 expression. Biochem Biophys Res Commun. 2021;575:78-84. [Citation Counts 5 as of May 2024]
2020
S-K.Kim, S.D.Jang, H.Kim, S.Chung, J.K.Park H.J.Kuh. Phenotypic Heterogeneity and Plasticity of Cancer Cell Migration in a Pancreatic Tumor Three-Dimensional Culture Model. Cancers, 12 (2020) 1305. [Citation Counts 24 as of May 2024]
H.H. Yun, S-K. Kim, H.J. Kuh, J.H. Lee, Downregulation of BIS sensitizes A549 cells for digoxin-mediated inhibition of invasion and migration by the STAT3-dependent pathway. Biochem Biophys Res Commun, 524 (2020) 643-648.
[Citation Counts 8 as of May 2024]
S. W. Son, H. Y. Lee, S. Moeng, H. J. Kuh, S. Y. Choi, J. K. Park. Participation of MicroRNAs in the Treatment of Cancer with Phytochemicals, Molecules, 20 (2020) 4701. [Citation Counts 15 as of May 2024]
S. Moeng, S. W. Son, J. S. Lee, T. H. Kim, S. Y. Choi, H. J. Kuh, J. K. Park. Extracellular Vesicles (EVs) and Pancreatic Cancer: From the Role of EVs to the Interference with EV-Mediated Reciprocal Communication, Biomedicines, 8 (2020) 267. [Citation Counts 27 as of May 2024]
S. Moeng, S. W. Son, H. A. Seo, J. S. Lee, C. K. Kim, H. J. Kuh, J. K. Park. Luteolin-regulated MicroRNA-301-3p Targets Caspase-8 and Modulates TRAIL Sensitivity in PANC-1 Cells, Anticancer Res, 40(2) (2020) 723-731.
[Citation Counts 20 as of May 2024]
M. S. Oh, I. A. Khawar, D. W. Lee, J. K. Park, H. J. Kuh. Three-Dimensional Imaging for Multiplex Phenotypic Analysis of Pancreatic Microtumors Grown on a Minipillar Array Chip. Cancers, 12 (2020) 3662. [Citation Counts 7 as of May 2024]
2019
H.A. Seo, S. Moeng, S. Sim, H.J. Kuh, S.Y. Choi, J.K. Park. MicroRNA-Based Combinatorial Cancer Therapy: Effects of MicroRNAs on the Efficacy of Anti-Cancer Therapies, Cells, 9 (2019) 29. [Citation Counts 59 as of May 2024]
H.J. Hwang, M.S. Oh, D.W. Lee, H.J. Kuh, Multiplex quantitative analysis of stroma-mediated cancer cell invasion, matrix remodeling, and drug response in a 3D co-culture model of pancreatic tumor spheroids and stellate cells, J Exp Clin Cancer Res, 38 (2019) 258. [Citation Counts 95 as of May 2024]
S. Nam, I.A. Khawar, J.K. Park, S. Chang, H.J. Kuh, Cellular context-dependent interaction between cancer and stellate cells in hetero-type multicellular spheroids of pancreatic tumor, Biochem Biophys Res Commun, 515 (2019) 183-189.
[Citation Counts 8 as of May 2024]
2018
S. Moeng, H.A. Seo, C.Y. Hwang, G.A. Cipolla, D.J. Lee, H.J. Kuh, J.K. Park, MicroRNA-107 Targets IKBKG and Sensitizes A549 Cells to Parthenolide, Anticancer Res, 38 (2018) 6309-6316. [Citation Counts 10 as of May 2024]
J.K. Park, J.S. Seo, S.K. Lee, K.K. Chan, H.J. Kuh, Combinatorial Antitumor Activity of Oxaliplatin with Epigenetic Modifying Agents, 5-Aza-CdR and FK228, in Human Gastric Cancer Cells, Biomol Ther (Seoul), 26 (2018) 591-598.
[Citation Counts 11 as of May 2024]
J. Lee, H.H. Yun, S. Kim, S.H. Ji, H.J. Kuh, J.H. Lee, Implication of BIS in the Migration and Invasion of A549 Non-small Cell Lung Cancer Cells, Anticancer Res, 38 (2018) 5057-5065. [Citation Counts 1 as of May 2024]
I.A. Khawar, J.K. Park, E.S. Jung, M.A. Lee, S. Chang, H.J. Kuh, Three Dimensional Mixed-Cell Spheroids Mimic Stroma-Mediated Chemoresistance and Invasive Migration in hepatocellular carcinoma, Neoplasia, 20 (2018) 800-812.
[Citation Counts 99 as of May 2024]
D.W. Lee, J. Kang, H.J. Hwang, M.-S. Oh, B.C. Shin, M.-Y. Lee, H.-J. Kuh, Pitch-tunable pillar arrays for high-throughput culture and immunohistological analysis of tumor spheroids, RSC Advances, 8 (2018) 4494-4502.
[Citation Counts 9 as of May 2024]
J.H. Lee, S.K. Kim, I.A. Khawar, S.Y. Jeong, S. Chung, H.J. Kuh, Microfluidic co-culture of pancreatic tumor spheroids with stellate cells as a novel 3D model for investigation of stroma-mediated cell motility and drug resistance, J Exp Clin Cancer Res, 37 (2018) 4. [Citation Counts 174 as of May 2024]
Lee, Jeehan; Yun, Hye Hyeon; Kim, Seulki; Ji, Sang Hee; Kuh, Hyo-Jeong; Lee, Jeong-Hwa Implication of BIS in the Migration and Invasion of A549 Non-small Cell Lung Cancer Cells, ANTICANCER RESEARCH,2018;38(8):4525-4533
[Citation Counts 1 as of May 2024]
2017
J.H. Kim, B.C. Shin, W.S. Park, J. Lee, H.J. Kuh, Antifibrotic effects of pentoxifylline improve the efficacy of gemcitabine in human pancreatic tumor xenografts, Cancer Sci, 108 (2017) 2470-2477. [Citation Counts 24 as of May 2024]
2016
J. Kang, D.W. Lee, H.J. Hwang, S.E. Yeon, M.Y. Lee, H.J. Kuh, Mini-pillar array for hydrogel-supported 3D culture and high-content histologic analysis of human tumor spheroids, Lab Chip, 16 (2016) 2265-2276. [Citation Counts 46 as of May 2024]
S.Y. Jeong, J.H. Lee, Y. Shin, S. Chung, H.J. Kuh, Co-Culture of Tumor Spheroids and Fibroblasts in a Collagen Matrix-Incorporated Microfluidic Chip Mimics Reciprocal Activation in Solid Tumor Microenvironment, PLoS One, 11 (2016) e0159013. [Citation Counts 279 as of May 2024]
2015
S.A. Kim, E.K. Lee, H.J. Kuh, Co-culture of 3D tumor spheroids with fibroblasts as a model for epithelial-mesenchymal transition in vitro, Exp Cell Res, 335 (2015) 187-196. [Citation Counts 116 as of May 2024]
I.A. Khawar, J.H. Kim, H.J. Kuh, Improving drug delivery to solid tumors: priming the tumor microenvironment, J Control Release, 201 (2015) 78-89. [Citation Counts 499 as of May 2024]
S.A. Kim, I. Kim, S.K. Yoon, E.K. Lee, H.J. Kuh, Indirect modulation of sensitivity to 5-fluorouracil by microRNA-96 in human colorectal cancer cells, Arch Pharm Res, 38 (2015) 239-248. [Citation Counts 48 as of May 2024]
2014
H. Lee, C. Kim, J.L. Ku, W. Kim, S.K. Yoon, H.J. Kuh, J.H. Lee, S.W. Nam, E.K. Lee, A long non-coding RNA snaR contributes to 5-fluorouracil resistance in human colon cancer cells, Mol Cells, 37 (2014) 540-546. [Citation Counts 87 as of May 2024]
S.H. Lee, J.K. Nam, J.K. Park, J.H. Lee, S. Min do, H.J. Kuh, Differential protein expression and novel biomarkers related to 5-FU resistance in a 3D colorectal adenocarcinoma model, Oncol Rep, 32 (2014) 1427-1434. [Citation Counts 16 as of May 2024]
2013
S.E. Yeon, Y. No da, S.H. Lee, S.W. Nam, I.H. Oh, J. Lee, H.J. Kuh, Application of concave microwells to pancreatic tumor spheroids enabling anticancer drug evaluation in a clinically relevant drug resistance model, PLoS One, 8 (2013) e73345. [Citation Counts 105 as of May 2024]
Y.J. Kim, S.H. Lee, J. Lee, H.J. Kuh, Non-nuclear localization of Ki-67 in human colorectal cancer cells grown as multicellular layers, Arch Pharm Res, 36 (2013) 634-640. [Citation Counts 6 as of May 2024]
J.H. Kim, J.H. Lee, K.S. Kim, K. Na, S.C. Song, J. Lee, H.J. Kuh, Intratumoral delivery of paclitaxel using a thermosensitive hydrogel in human tumor xenografts, Arch Pharm Res, 36 (2013) 94-101. [Citation Counts 20 as of May 2024]
H. Kim, G.H. Lee, J. Ro, H.J. Kuh, B.K. Kwak, J. Lee, Recoverability of freeze-dried doxorubicin-releasing chitosan embolic microspheres, J Biomater Sci Polym Ed, 24 (2013) 2081-2095. [Citation Counts 4 as of May 2024]
S.B. Jang, D. Kim, S.Y. Kim, C. Park, J.H. Jeong, H.J. Kuh, J. Lee, Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats, Korean J Physiol Pharmacol, 17 (2013) 9-13. [Citation Counts 12 as of May 2024]
2012
Y. Sohn, S.Y. Lee, G.H. Lee, Y.J. Na, S.Y. Kim, I. Seong, B.J. Lee, H.J. Kuh, J. Lee, Development of self-microemulsifying bilayer tablets for pH-independent fast release of candesartan cilexetil, Pharmazie, 67 (2012) 917-924. [Citation Counts 24 as of May 2024]
J.M. Park, S.Y. Lee, G.H. Lee, E.Y. Chung, K.M. Chang, B.K. Kwak, H.J. Kuh, J. Lee, Design and characterisation of doxorubicin-releasing chitosan microspheres for anti-cancer chemoembolisation, J Microencapsul, 29 (2012) 695-705. [Citation Counts 36 as of May 2024]
J.H. Lee, K. Na, S.C. Song, J. Lee, H.J. Kuh, The distribution and retention of paclitaxel and doxorubicin in multicellular layer cultures, Oncol Rep, 27 (2012) 995-1002. [Citation Counts 20 as of May 2024]
S.Y. Kim, Y.J. Na, D. Kim, Y. Kim, H.M. Kim, S.H. Hwang, J. Kwak, H.J. Kuh, J. Lee, Development of estimation methods of skin oxidation and evaluation of anti-oxidative effects of genistein in topical formulations, Korean J Physiol Pharmacol, 16 (2012) 205-209. [Citation Counts 5 as of May 2024]
S.Y. Kim, T.H. Kim, J.H. Choi, K.C. Lee, K.D. Park, S.J. Lee, H.J. Kuh, Evaluation of interstitial protein delivery in multicellular layers model, Arch Pharm Res, 35 (2012) 531-541. [Citation Counts 4 as of May 2024]
E.Y. Chung, H.M. Kim, G.H. Lee, B.K. Kwak, J.S. Jung, H.J. Kuh, J. Lee, Design of deformable chitosan microspheres loaded with superparamagnetic iron oxide nanoparticles for embolotherapy detectable by magnetic resonance imaging, Carbohydr Polym, 90 (2012) 1725-1731. [Citation Counts 54 as of May 2024]
J.K. Cho, C. Chun, H.J. Kuh, S.C. Song, Injectable poly(organophosphazene)-camptothecin conjugate hydrogels: synthesis, characterization, and antitumor activities, Eur J Pharm Biopharm, 81 (2012) 582-590. [Citation Counts 47 as of May 2024]
2011
S.H. Kim, H.J. Kuh, C.R. Dass, The reciprocal interaction: chemotherapy and tumor microenvironment, Curr Drug Discov Technol, 8 (2011) 102-106. [Citation Counts 23 as of May 2024]
N. Kim, S.H. Kim, Y.J. Kim, J.K. Kim, M.K. Nam, H. Rhim, S.K. Yoon, S.Z. Choi, M. Son, S.Y. Kim, H.J. Kuh, Neurotrophic activity of DA-9801, a mixture extract of Dioscorea japonica Thunb. and Dioscorea nipponica Makino, in vitro, J Ethnopharmacol, 137 (2011) 312-319. [Citation Counts 40 as of May 2024]
M.S. Choi, S.H. Kim, H.J. Kuh, Penetration of paclitaxel and 5-fluorouracil in multicellular layers of human colorectal cancer cells, Oncol Rep, 25 (2011) 863-870. [Citation Counts 16 as of May 2024]
2010
A.M. Al-Abd, K.Y. Hong, S.C. Song, H.J. Kuh, Pharmacokinetics of doxorubicin after intratumoral injection using a thermosensitive hydrogel in tumor-bearing mice, J Control Release, 142 (2010) 101-107. [Citation Counts 145 as of May 2024]
1994~2009
S.H. Kim, S.J. Choi, Y.C. Kim, H.J. Kuh, Anti-tumor activity of noble indirubin derivatives in human solid tumor models in vitro, Arch Pharm Res, 32 (2009) 915-922.
W.H. Chung, B.H. Sung, S.S. Kim, H. Rhim, H.J. Kuh, Synergistic interaction between tetra-arsenic oxide and paclitaxel in human cancer cells in vitro, Int J Oncol, 34 (2009) 1669-1679.
A.M. Al-Abd, S.H. Lee, S.H. Kim, J.H. Cha, T.G. Park, S.J. Lee, H.J. Kuh, Penetration and efficacy of VEGF siRNA using polyelectrolyte complex micelles in a human solid tumor model in-vitro, J Control Release, 137 (2009) 130-135.
A.M. Al-Abd, N.H. Kim, S.C. Song, S.J. Lee, H.J. Kuh, A simple HPLC method for doxorubicin in plasma and tissues of nude mice, Arch Pharm Res, 32 (2009) 605-611.
S.J. Choi, H.J. Hur, S.B. Lee, M.S. Choi, H.J. Kuh, Y.H. Shin, H.J. Lee, A simple HPLC method for the quantification of mizoribine in human serum: pharmacokinetic applications, Biomed Chromatogr, 22 (2008) 1259-1264.
A.M. Al-Abd, J.H. Lee, S.Y. Kim, N. Kun, H.J. Kuh, Novel application of multicellular layers culture for in situ evaluation of cytotoxicity and penetration of paclitaxel, Cancer Sci, 99 (2008) 423-431.
J.W. Lee, J.K. Park, S.H. Lee, S.Y. Kim, Y.B. Cho, H.J. Kuh, Anti-tumor activity of heptaplatin in combination with 5-fluorouracil or paclitaxel against human head and neck cancer cells in vitro, Anticancer Drugs, 17 (2006) 377-384.
H.K. Cho, E.S. Lee, J.W. Lee, J.K. Park, J.H. Kang, K.S. Lee, C.K. Shim, S.J. Chung, D.D. Kim, H.J. Kuh, Clinical pharmacokinetics of oxaliplatin and 5-fluorouracil administered in combination with leucovorin in Korean patients with advanced colorectal cancer, J Cancer Res Clin Oncol, 132 (2006) 320-326.
J.K. Park, S.H. Lee, J.H. Kang, K. Nishio, N. Saijo, H.J. Kuh, Synergistic interaction between gefitinib (Iressa, ZD1839) and paclitaxel against human gastric carcinoma cells, Anticancer Drugs, 15 (2004) 809-818.
Y.R. Kim, H.J. Kuh, M.Y. Kim, Y.S. Kim, W.C. Chung, S.I. Kim, M.W. Kang, Pharmacokinetics of primaquine and carboxyprimaquine in Korean patients with vivax malaria, Arch Pharm Res, 27 (2004) 576-580.
J. Usuda, M. Inomata, H. Fukumoto, Y. Iwamoto, T. Suzuki, H.J. Kuh, K. Fukuoka, H. Kato, N. Saijo, K. Nishio, Restoration of p53 gene function in 12-O-tetradecanoylphorbor 13-acetate-resistant human leukemia K562/TPA cells, Int J Oncol, 22 (2003) 81-86.
I.S. Park, M.R. Ahn, S.K. Suh, H.S. Choi, S.J. Sohn, J.S. Yang, T.M. Yoo, H.J. Kuh, In vitro pharmacodynamics of CKD-602 in HT-29 cells, Arch Pharm Res, 25 (2002) 718-723.
H.W. Park, S.J. Chung, H.J. Kuh, S.J. Chung, M.G. Lee, C.K. Shim, The transport of a hepatoprotective agent, isopropryl 2-(1-3-dithiethane-2-ylidene)-2[N-(4-methyl-thiazole-2-yl) carbamoyl] acetate (YH439), across Caco-2 cell monolayers, Arch Pharm Res, 24 (2001) 584-589.
J. Usuda, N. Saijo, K. Fukuoka, H. Fukumoto, H.J. Kuh, T. Nakamura, Y. Koh, T. Suzuki, F. Koizumi, T. Tamura, H. Kato, K. Nishio, Molecular determinants of UCN-01-induced growth inhibition in human lung cancer cells, Int J Cancer, 85 (2000) 275-280.
T. Suzuki, H. Sasaki, H.J. Kuh, M. Agui, Y. Tatsumi, S. Tanabe, M. Terada, N. Saijo, K. Nishio, Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts, Gene, 242 (2000) 167-173.
H.J. Kuh, S. Nakagawa, J. Usuda, K. Yamaoka, N. Saijo, K. Nishio, A computational model for quantitative analysis of cell cycle arrest and its contribution to overall growth inhibition by anticancer agents, Jpn J Cancer Res, 91 (2000) 1303-1313.
H.J. Kuh, S.H. Jang, M.G. Wientjes, J.L. Au, Computational model of intracellular pharmacokinetics of paclitaxel, J Pharmacol Exp Ther, 293 (2000) 761-770.
H.J. Kuh, S.H. Jang, M.G. Wientjes, J.R. Weaver, J.L. Au, Determinants of paclitaxel penetration and accumulation in human solid tumor, J Pharmacol Exp Ther, 290 (1999) 871-880.
H. Fukumoto, T. Tamura, Y. Kamiya, J. Usuda, T. Suzuki, F. Kanzawa, H.J. Kuh, Y. Ohe, N. Saijo, K. Nishio, Activation-induced apoptosis of peripheral lymphocytes treated with 7-hydroxystaurosporine, UCN-01, Invest New Drugs, 17 (1999) 335-341.
J.L. Au, D. Li, Y. Gan, X. Gao, A.L. Johnson, J. Johnston, N.J. Millenbaugh, S.H. Jang, H.J. Kuh, C.T. Chen, M.G. Wientjes, Pharmacodynamics of immediate and delayed effects of paclitaxel: role of slow apoptosis and intracellular drug retention, Cancer Res, 58 (1998) 2141-2148.
H.J. Kang, M.G. Wientjes, J.L. Au, Physiologically based pharmacokinetic models of 2',3'-dideoxyinosine, Pharm Res, 14 (1997) 337-344.
T.K. Yeh, H.J. Kang, M.G. Wientjes, J.L. Au, Pharmacokinetic interaction between intravenous 2',3'-dideoxyinosine and pentamidine in rats, Pharm Res, 13 (1996) 628-632.
H.J. Kang, M.G. Wientjes, J.L. Au, Tissue pharmacokinetics of 2',3'-dideoxyinosine in rats, Biochem Pharmacol, 48 (1994) 2109-2116.
H.J. Kuh, C.K. Shim, Nonlinear renal excretion of theophylline and its metabolites, 1-methyluric acid and 1,3-dimethyluric acid, in rats, Arch Pharm Res, 17 (1994) 124-130.
IN preparation
K-S. Kim, M.K Hong, J.H. Kim, S-J Lee, H.J. Kuh. Calvarial defect regeneration by poly-L-lactide(PLLA) scaffold with coated of bFGF gene and PTD complexes.
K-S. Kim, J.H. Kim, E.Y. Chung, J. Lee, H.J. Kuh. Distribution of DOX-chitosan microspheres in VX2 rabbit auricles model.
특허 (Patent)
6. 구효정, 강지훈 (가톨릭대학교 산학협력단) 마이크로필러를 이용한 시료 박편의 제조방법.(Method for preparing section sample using micropillar) 대한민국 특허 제 10-2145344호 (등록일 2020년 08월 11일, 출원번호 10-2016-0026619 출원일 2017년 03월 03일)
5. 구효정, 강지훈 (가톨릭대학교 산학협력단) 필러 조립체 및 이를 포함하는 시료 블록의 제조장치.(Pillar assembly and preparing apparatus for sample block comprising the same) 대한민국 특허 제10-1860502호 (등록일 2018년 05월 18일, 출원번호 제10-2016-0140137호 (2018.05.16)
4. 구효정, 강지훈 (가톨릭대학교 산학협력단) 마이크로필라를 이용한 시료 박편의 제조방법.(Method for preparing section sample using micropillar) ( 출원번호 10-2016-0026619 (접수번호 1-1-2016-0214670-23). 등록예정
3. 구효정, 김정호 (가톨릭대학교 산학협력단) 펜톡시필린을 포함하는 항암치료 보조제.(anti-cancer adjuvant comprising pentoxifylline) 대한민국 특허 제10-1512223호 (등록일 2015년 04월 08일, 출원번호 제10-2013-0019207호(2013.02.22.) 미국 특허 US20150374702 출원 (공개일 2015년 12월 31일, 출원일 2013년 10월 04일)
2. 구효정, 아메드 알-압드, 이주호 (가톨릭대학교 산학협력단) 다층 암세포 배양계에서 칼세인-AM을 이용한 항암 물질또는 항암 처리 방법의 스크리닝 방법. 대한민국 특허 제10-0892980호 (등록일 2009년 04월 03일, 출원번호 제 2007-0038878호(2007.04.20).
1. 구효정, 이정원,김성윤, 심창구, 정석재 (가톨릭대학교 산학협력단) 세포독성 분석법과 결합된 다층 암세포 배양계를 이용한 항암물질의 활성 측정 방법. 대한민국 특허 제10-10689107호 (등록일 2007년 02월 23일, 출원번호 제 2004-0037541호(2004.05.24).